Alabama-native Jacqueline Fox was posthumously awarded $72 million in February and ovarian cancer survivor Gloria Ristesund was awarded $55 million in May.
Johnson & Johnson lost a third straight trial over claims its talcum powder can cause ovarian cancer, with a St. Louis jury awarding a California woman more than AU$92 million (US$70 million).
Johnson & Johnson will appeal the verdict, its spokeswoman Carol Goodrich said.
Deborah Giannecchini was diagnosed with Stage 4 ovarian cancer, having to have her spleen, colon, uterus and ovaries removed, according to a press release from the law firm representing her.
The suit accused J&J of "negligent conduct" in making and marketing its baby powder.
"We deeply sympathize with the women and families impacted by ovarian cancer", said a company spokesperson. Earlier this year, two other lawsuits in St. Louis also ended in verdicts that awarded the plaintiffs large amounts of money.
All three cases were handled by the Onder Law Firm of Webster Groves, which has advertised nationwide for ovarian cancer patients who suspect baby powder may be linked to their disease.
Based on limited evidence from human studies of a link to ovarian cancer, the World Health Organisation's International Agency for Research on Cancer classifies the perineal (genital) use of talc-based body powder as "possibly carcinogenic to humans".
When her trial began in late September Ms Giannecchini was seeking $275m (£226m) in costs and damages. The studies found woman that use talc on their genital area are up to 40 percent more likely to develop the cancer.
Johnson & Johnson is an iconic name brand for personal hygiene and baby products.
The victim said that she was overwhelmed by the verdict as she "waited for a long time for this".
JNJ has denied any link to talc use and ovarian cancer.
False. Talc, a natural mineral comprised of magnesium, silicon and oxygen, is often used in powders meant to absorb moisture and reduce friction.
Prior to the recent litigation, suspicions about the risks of talc were almost unknown outside of the scientific community. J&J faces more than 1,700 lawsuits regarding baby powder and shower-to-shower gel promoted by the company.
Johnson & Johnson has been targeted before by health and consumer groups over ingredients in its products, including Johnson's No More Tears baby shampoo.