At least 12 regime fighters and 20 IS militants were among the dead in the IS attack on government positions.
The Syrian Observatory for Human Rights said Saturday's offensive was the most intense since mid-January 2016, when the group killed dozens of people, majority pro-government militiamen, in wide-scale attacks on the city that saw the group make significant advances.
The forces deployed at the airfield managed to repel the attacks having killed many terrorists and damaged three tanks.
IS began the assault by simultaneously storming the Al-Baghiliyah and Al-Rashidiyah districts of Deir ez-Zor city; this resulted in a fierce battle with the Syrian Arab Army's 123rd Brigade. Daesh, a terrorist organization outlawed in many countries, including the United States and Russian Federation, took over large swathes of Syria and Iraq the same year.
Following the missile strike, the Syrian Air Force took the initiative and began launching nonstop airstrikes over the Islamic State's positions inside the city.
Deir al-Zor province links Islamic State's de facto capital in the Syrian city of Raqqa with territory controlled by the militant group in Iraq.