"Eden has suffered an injury before the match against Stoke, it does not look so serious", he was quoted as saying in Belgian media.
The midfielder will also be unavailable for the Belgium match against Greece and will be monitored by the medical team.
The Belgium boss revealed on Monday that Hazard will miss 10-15 days - leaving his participation in Chelsea's next game, against Crystal Palace in 12 days' time, a continuing concern. "We are going to follow the injury", Martínez said.
The former Player of the Year has not travelled with the Belgium squad during the worldwide break.
"A big test awaits without Eden".
Chelsea star Eden Hazard will miss Belgium's worldwide commitments due to a calf problem.
Hazard was initially expected to be fit enough to feature in national side Belgium's upcoming games against Russian Federation and Greece, but he pulled out of the squad on Monday morning to undergo further treatment. If you want to be a good team, you have to absorb everything.
Chelsea, who are now 10 points clear at the top of the Premier League, welcome Crystal Palace to Stamford Bridge in 12 days time.
"Hazard in the last training felt a bit of a problem in his calf and for this reason I preferred not to risk him".